Diagnostic dilemma in flaccid paralysis following anti-rabies vaccine.

Differentiating paralytic rabies from post antirabies vaccine polyradiculoneuropathy.

Sir, The recent report of flaccid paralysis following anti-rabies vaccine (ARV) was interesting, where Behari et al describe the diagnostic dilemma in a patient presenting with flaccid paralysis following administration of ARV. They mention that measurement of rabies antibody titer in the serum and cerebrospinal fluid could help in differentiating paralytic rabies from post-ARV polyradiculoneur...

Genomic Analysis of Vaccine-Like Poliovirus Isolates from Stool Specimens of Acute Flaccid Paralysis Cases with Residual Paralysis during the Years 1380-1381 in Iran

Presence of Virus Neutralizing Antibodies in Cerebral Spinal Fluid Correlates with Non-Lethal Rabies in Dogs

BACKGROUND Rabies is traditionally considered a uniformly fatal disease after onset of clinical manifestations. However, increasing evidence indicates that non-lethal infection as well as recovery from flaccid paralysis and encephalitis occurs in laboratory animals as well as humans. METHODOLOGY/PRINCIPAL FINDINGS Non-lethal rabies infection in dogs experimentally infected with wild type dog ...

Rabies virus neuritic paralysis: immunopathogenesis of nonfatal paralytic rabies.

Two pathogenetically distinct disease manifestations are distinguished in a murine model of primary rabies virus infection with the Evelyn-Rokitnicky-Abelseth strain, rabies virus neuritic paralysis (RVNP) and fatal encephalopathogenic rabies. RVNP develops with high incidence in immunocompetent mice after intraplantar infection as a flaccid paralysis restricted to the infected limb. The histop...

Vaccines against Botulism

Botulinum neurotoxins (BoNT) cause the flaccid paralysis of botulism by inhibiting the release of acetylcholine from motor neurons. There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was used to vaccinate people who are at high risk of contracting botulism. Howe...

A Sri Lankan infant with vaccine associated acute flaccid paralysis.

Global incidence of poliomyelitis has reduced by more than 99% since the Global Polio Eradication Initiative was launched in 1988 [1]. In par with the global trend, Sri Lanka has achieved great success with no reported cases since 1993, but still is not declared as a country which has eradicated polio due to prevalence of polioyomyelitis in neighbouring countries [2]. Countries which have eradi...